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KMID : 0604520150410030263
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Journal of the Society of Cosmetic Scientists of Korea
2015 Volume.41 No. 3 p.263 ~ p.268
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Melanogenesis Inhibitory Activities of Mulberry Seed Ethanol Extracts
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Jeong Yong-Tae
Kang Min-Ju
Kim Jin-Hee
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Abstract
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The purpose of this study was to investigate anti-melanogenesis effects of mulberry seed extracts (MSE). MSE inhibited melanogenesis in melan-a cells at 10 μg/mL without cytotoxicity. Also, MSE decreased tyrosinase, tyrosinase-related protein-1 (TRP-1) protein expression in the melan-a cells. To identify the signaling pathway of MSE, the ability of MSE to influence extracellular signal-regulated protein kinase (ERK) activation was investigated. MSE induced ERK protein expression in a dose-dependent manner. In addition, MSE presented inhibition of the body pigmentation in vivo zebrafish model. These results suggest that MSE may be an effective anti-melanogenesis agent regulating the expression of ERK protein and melanogenic enzymes.
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KEYWORD
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Mulberry seed, melanogenesis, melan-a, zebrafish, ethanol extract
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